The Galli-Curci Theatre is located on Main Street (state highway NY 30) in Margaretville, New York, United States. It is a brick building erected in the 1920s, now primarily used as a store, although some of the original theater remains. It was named after opera singer Amelita Galli-Curci, who lived near Margaretville and sang at its opening night.
It was built by local entrepreneur Clarke Sanford to house two pioneering businesses in the region, a car dealership and silent movie theater and offices of the Catskill Mountain News. Under later owners, it continued to show movies until 1985. It was modified afterwards for reuse as an antique store, but has remained mostly intact from its period of cinematic use. In 2006 it was listed on the National Register of Historic Places.