The famous train wreck scene in the 1993 Warner Brothers blockbuster movie The Fugitive starring Harrison Ford and Tommy Lee Jones was filmed in Dillsboro along the Great Smoky Mountains Railroad. The wreckage set can still be viewed on eastbound Tuckasegee River Excursions departing from Bryson City.
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Train scenes in the 1998 DreamWorks SKG film Forces of Nature starring Ben Affleck and Sandra Bullock were also filmed on the Great Smoky Mountains Railroad.