Kanawha Hotel is a historic hotel located at Elizabeth, Wirt County, West Virginia. It is a two story, log core, clapboard covered building which gained its present appearance about 1870 with several frame additions. The original section was built about 1800, and is possibly the oldest building in the county. The hotel operated from 1812 to 1928, after which it was sold as a private residence. Also on the property is a 19th century well pavilion with a pyramidal roof.
It was listed on the National Register of Historic Places in 1986.