Some of the more interesting pieces of the collection are wax model of a woman with a human horn growing out of her forehead, the tallest human skeleton on display in North America, a 5'-long human colon that contained over 40 pounds of fecal matter upon its removal, the petrified body of the mysterious Soap Lady, a malignant tumor removed from President Grover Cleveland's hard palate, the conjoined liver from Siamese twins Chang and Eng Bunker, and a growth removed from President Lincoln's assassin, John Wilkes Booth.
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Besides being home to the Mütter the building also houses The College of Physicians of Philadelphia which, founded in 1787, is the oldest professional medical organization in the United States.