Niles Amtrak station

The Amtrak station is located along the main line east of the former Benton Harbor Branch crossing and west of the former junctions with the South Bend and Air Line Branches. Amtrak uses the old Michigan Central Railroad station; the current structure was built in 1892 and is listed on the National Register of Historic Places.

Niles Depot has been used in on-locations scenes of at least three movies. Continental Divide, starring John Belushi and Blair Brown, Midnight Run, starring Robert De Niro and Charles Grodin, and Only the Lonely starring John Candy and Ally Sheedy. It was the latter of these three which spawned a tradition of adding Christmas lights and decorations around the station annually. It was also featured in Planes, Trains and Automobiles.