In the film Run Fatboy Run, the character Whit owns an apartment in 1 West India Quay. Also, earlier in the film, he is heard saying "West India Quay please!" to a taxi driver.
Much of the music video 'Heartbroken' by T2 (a London based, garage music band) was filmed in or around 1 West India Quay.
Whilst still a construction site, the building was used as a location in the film, Layer Cake, starring Daniel Craig.
The introduction of the show Richard Hammond's Invisible Worlds was filmed on the rooftop of 1 West India Quay, with Richard Hammond standing close to the building's signature arched top.