In the infancy of the AIDS epidemic, Klein became one of the first doctors in Los Angeles to diagnose a case of Kaposi's sarcoma in a young patient.
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He received numerous awards and honors including Who's Who in the World, Best Doctors in America, Men of Achievement, AIDS Services Foundation of Orange County, Award of Merit, Los Angeles Magazine, The Best of L.A.,
In 2004, Klein was given a chair in his name at the UCLA Division of Dermatology.