The show starred Australian stand-up comedian Jim Jefferies, who played himself. D.J. Qualls played Billy Nugent, who had muscular dystrophy and was restricted to an electric wheelchair and an oxygen machine. Dan Bakkedahl played Billy's brother Steve. The three of them lived in this house on the show. The show also starred Mindy Sterling, John Ratzenberger, Sonya Eddy, and Nick Daley.
The house looked a little different in the show. It was painted blue and had a fake address number on the front wall. I found this location after briefly spotting a street sign in an episode.
They filmed scenes inside and in front of this home, but I think the backyard scenes were filmed elsewhere.