The Stonewall Inn was the site of the famous Stonewall riots of 1969, which have come to symbolize the beginning of the gay liberation movement in the United States. A little known fact is that the Genovese Crime Family ran quite a few gay bars including The Stonewall Inn.
Also seen here at VG:
http://virtualglobetrotting.com/map/stonewall-inn-site-of-the-stonewall-riots/