The Piru Mansion has been shown in numerous films, as well as television and commercials. Some of the films the mansion has been used in are: Murder She Wrote, Charlie's Angels, The Incredible Hulk, Payne, Ping!, American Wedding, and many others.
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Some of the actors and actresses who have acted in productions shot at the Piru Mansion include: Shelley Winters, June Allyson, Buddy Ebsen, Ricardo Montalban, Robert Duvall, Patty Duke, James Garner, Angela Lansbury, Shirley Jones, John Larroquette and many more.