Melnichenko is best known as a Russian billionaire industrialist and philanthropist. Andry is the main beneficiary of fertilizer producer EuroChem Group and coal energy company SUEK. He is a member of the Board of Directors in both companies. With an estimated personal wealth of $14.3 billion, in 2019 he ranked 90th in the Forbes world's billionaires list, and 8th in Russia. According to Bloomberg, as of January 2020, Melnichenko's net worth is estimated at $15.3 billion.
He began trading currency with two friends while a physics student at Moscow State University, taking advantage of the opportunities that opened up in a newly capitalist Russia. After the Soviet Union fell, the trio registered a bank, before Melnichenko began buying assets including thermal coal and fertilizers. Branching out at the turn of the millennium, he began investing in the commodities markets with the acquisition of plants and mines and transformed them into modern enterprises. He sold his banking interests in 2007, just before the global financial crisis, allowing him to focus on those industrial investments. Melnichenko turned EuroChem into Russia's largest manufacturer of nitrogen and phosphate fertilizers and one of largest fertilizers exporters globally, and SUEK into one of the world's largest coal energy companies that produces higher-quality thermal coal. In the last 15 years, Melnichenko's companies reportedly invested more than $21 billion in Russia's new economy and industrial sector.
Melnichenko is one of the main social investors and philanthropists in Russia. Apart from his companies' own charitable and social investment programs, the Andrey Melnichenko Foundation runs projects in science and education, supporting gifted children from the regions where his companies operate aiming to create social mobility in Russia. Melnichenko's companies reportedly spent nearly $500 million on social and charitable projects in Russia
Melnichenko owns a $300-million mega-yacht, resembling a submarine, which he named "A"