In his first full season in the Premier League, Owen finished as joint top scorer with 18 goals. Then, to show everyone he meant business, he repeated this the following year and was Liverpool's top goal-scorer from 1997–2004, gaining his name as a proven goal-scorer despite suffering from a recurring hamstring injury that often hurt his performance on the field. In 2001, Liverpool won a cup treble of the UEFA Cup, FA Cup and Football League Cup, and Owen was the recipient of the Ballon d'Or. He went on to score 118 goals in 216 appearances in the Premier League for Liverpool, and 158 goals in 297 total appearances. Regarded as one of the greatest Liverpool players, Owen was named by Pelé in the FIFA 100 list of the world's greatest living players.
Owen moved to Real Madrid for £8 million in mid-2004; he was frequently used as a substitute. He scored 13 goals in La Liga before returning to England the following season where he joined Newcastle United for £16.8 million. After a promising start to the 2005–06 season, again that hamstring injury largely ruled him out over the next 18 months. After his return, he became team captain and was the team's top scorer for the 2007–08 season. Newcastle were relegated in the 2008–09 season and Owen moved to Manchester United as a free agent. He spent three years at Old Trafford before joining Stoke City in September 2012. Owen is one of nine players to have scored 150 or more goals in the Premier League. He is also the youngest player to have reached 100 goals in the Premier League. On 19 March 2013, Owen announced his retirement from playing at the end of the 2012–13 season.