Jalpan de Serra is a town and municipality located in the north of the state of Querétaro, Mexico. It is located in the heart of an important ecological zone called the Sierra Gorda. It is also the site two of five Franciscan missions, including the first one, to have been built in the mid-18th century, and declared a World Heritage Site in 2003. The municipality is also home to a small but important indigenous group called the Pame. However, the municipality has been losing population since the mid-20th century even though recent events such as the town being named a Pueblo Mágico have worked to create a tourism industry.
The municipality has two of the five Franciscan missions accredited to Junípero Serra during his evangelization of the Sierra Gorda. These missions were declared a World Heritage Site in 2003. One is located in the town of Jalpan proper and the other is located in the community of Tancoyol.