The Sanderson Amtrak station is a flag stop train station in Sanderson, Texas, United States served by Amtrak, the national railroad passenger system.
Between 2007 and 2010, Sanderson was the least-used Amtrak stop in its national system.
The stop was formerly the site of a Galveston, Harrisburg, and San Antonio Railroad (GH&SA) depot, later owned by Southern Pacific and Union Pacific. A large prefabricated clapboard wooden depot was assembled at the site in 1882 and expanded in 1910. After Southern Pacific abandoned the depot in 1995, the building began to rapidly deteriorate. An effort to save the depot was made by the Sanderson Depot Association, although the group was unable to secure funding to move the depot. The depot was demolished in October 2012.