Ephraim McDowell House

The Dr. Ephraim McDowell House, also known as McDowell House, was a home of medical doctor Ephraim McDowell.

The home was declared a U.S. National Historic Landmark in 1966.

On December 13, 1809, Dr. McDowell diagnosed an ovarian tumor in Jane Todd Crawford of Green County, Kentucky, In his house on Christmas morning, 1809, Dr. McDowell removed a 22.5 pounds (10.2 kg) tumor without anesthetic or antisepsis. Mrs. Crawford made an uncomplicated recovery, returning to her home 25 days later and living another 32 years. This was the first successful removal of an ovarian tumor in the world.