The Mortirolo Pass has been featured in Giro d'Italia several times. The first time was in Stage 15 of 1990 Giro d'Italia, between Morbegno and Aprica, using the road from Mazzo di Valtellina.
Since Marco Pantani died in early 2004, stages of the Giro that go over Mortirolo feature a special prize to the first man at the top of the pass called Cima Pantani. A monument to deceased Marco Pantani was erected in 2006 by the Italian Professional Riders Association in the eighth kilometer of the road from Mazzo di Valtellina.