The Colorado and Southern Railway (reporting marks C&S, CS) was a railroad company in the western United States that operated independently from 1898 to 1908, then as part of the Chicago, Burlington and Quincy Railroad until it was absorbed into the Burlington Northern Railroad in 1981.
The railway began as the consolidation of bankrupt railroads on 1898. The Colorado Central Railroad and Cheyenne and Northern Railway were brought together to form the Union Pacific, Denver and Gulf Railway in 1890. When Union Pacific went bankrupt in 1893 they were separated from the Union Pacific and united with the Denver, Leadville and Gunnison Railway and others, by Frank Trumbull to form the Colorado and Southern Railroad in 1898. In 1908 the Chicago, Burlington and Quincy Railroad bought control of the C&S. It would later merge into the Burlington Northern Railroad in 1981.